With port binding, you create a separate VMkernel port for each physical NIC using 1:1 mapping.
You can add all network adapter and VMkernel port pairs to a single vSwitch. The vSphere Storage documentation explains in detail how to specify port binding.
You cannot set up ports for multipathing by using vicfg-iscsi.
In the examples below, specify one of the options listed in Connection Options for vCLI Host Management Commands in place of <conn_options>.
Verify that you are familiar with iSCSI session removal. See Removing iSCSI Sessions.