Removing and Updating Datastores

The Web Services API has methods to update and remove datastores.

RemoveDatastore – Removes a datastore from a host.
UpdateLocalSwapDatastore – Choose the localSwapDatastore for this host. Any change to this setting affects virtual machines that subsequently power on or resume from a suspended state at this host, or that migrate to this host while powered on. Virtual machines that are currently powered on at this host are not affected.

See the vSphere API Reference for more information about the HostDatastoreSystem operations, including constraints and limitations.